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Publikationen der Arbeitsgruppe

  1. Ziegler AG, Janka HU, Meister P, Spelsberg F, Mehnert H.  Multiple endokrine Neoplasie Typ IIb mit Ganglioneuromatose der Gallenblase, Cholelithiasis und Kleinhirndysplasie.  Akt Endokrin Stoff 7:156 159, 1986.
  2. Ziegler AG, Janka HU, Mehnert H. Transitorische ischämische Attacken bei Hyperparathyreoidismus. Dtsch med Wschr 112:345-347,1987.
  3. Ziegler AG, Standl E, Lander T, Nerl C, Rieber EP, Mehnert H.  Cell mediated auotimmunity at the onset of Type I diabetes mellitus. Klin Wschr 65:546-550,1987.
  4. Ziegler AG, Standl E.  Loss of Ia-positive Langerhans cells at the onset of Type 1 (insulin-dependent) diabetes mellitus.  Diabetologia 31:362-365,1988.
  5. Vardi P, Ziegler AG, Mathews JH, Dib SA, Keller RJ, Ricker AT, Wolfsdorf JI, Herskowitz RD, Rabizadeh A, Eisenbarth GS, Soeldner JS. Concentrations of insulin autoantibodies at onset of Type 1 diabetes: inverse log-linear correlation with age. Diabetes Care 11:736-739, 1988.
  6. Canadian European Randomized Control Trial Group. Cyclosporin-induced remission of IDDM after early intervention.  Association of 1 yr of Cyclosporin treatment with enhanced insulin secretion.  Diabetes 37:1574-82, 1988.
  7. Park JW, Ziegler AG, Janka HU, Doering W, Mehnert H.  Left ventricular relaxation and filling pattern in diabetic heart muscle disease: An echocardiographic study.  Klin Wschr 66:773-778, 1988.
  8. Ziegler AG, Vardi P, Ricker AT, Hattori M, Soeldner JS, Eisenbarth GS. Radioassay determination of insulin autoantibodies in NOD mice. Correlation with increased progression to overt diabetes.  Diabetes 38:358-63, 1989.
  9. Ziegler AG, Vardi P. Gross D, Bonner-Weir S, Villa-Komaroff L, Halban P, Ikegami H, Soeldner JS, Eisenbarth GS.  Production of insulin antibodies by mice rejecting insulin gene transfected cells.  J Autoimmunity 2:219-227, 1989.
  10. Ziegler AG, Ziegler R, Vardi P, Jackson RA, Soeldner JS, Eisenbarth GS. Life table analysis of progression to diabetes of anti-insulin autoantibody positive relatives of Type 1 diabetics.  Diabetes 38:1320-25, 1989.
  11. Standl R, Stiegler H, Rebell B, Ziegler AG, Schauer G, Roth R, Schulz K, Lehmacher W, Standl E: Der Typ-II-Diabetes in der Praxis des niedergelassenen Arztes: -Konzept einer zentrumsunterstützten Betreuung und Ergebnisse einer Stichproben-Erhebung im Großraum München. Akt. Endokr Stoffw 11:233-235, 1990.
  12. Ziegler AG, Baumgartl HJ, Standl E, Mehnert H: Risk of progression to diabetes of "low titer ICA" positive first degree relatives of Type 1 diabetics in Southern Germany. J Autoimmunity 3:619-624, 1990.
  13. Ziegler AG, Baumgartl HJ, Ede G, Held M, Vogt H, Kolb HJ, Standl E: Low pigment skin type and predisposition for development of type 1 diabetes? Diabetes Care 13:529-31, 1990.
  14. Ziegler AG, Standl E, Albert E, Mehnert H. HLA-associated insulin autoantibody (IAA) formation in newly diagnosed type 1 (insulin  dependent) diabetic patients. Diabetes 40:1146-49, 1991.
  15. Ziegler AG, Rabl W, ALbert E, Standl E. Insulin-Autoantikörper und Inselzell-Antikörper in Abhängigkeit vom Manifestationsalter und HLA  Phänotyp bei Patienten mit neumanifestem Typ-I-Diabetes mellitus. Dtsch med Wschr 116: 1737-1741, 1991.
  16. Martin S, Pawlowski B, Greulich B, Ziegler AG, Mandrup-Poulsen T, Mahon J. The natural course of remission in type 1 (insulin-dependent) diabetes during the first year after diagnosis. Diabetes Care 15: 66-74, 1992.
  17. Baumgartl HJ, Standl E, Schmidt-Gayk H, Kolb HJ, Janka HU, Ziegler AG. Changes of Vitamin D3 serum concentrations at the onset of immune  mediated type 1 (insulin-dependent) diabetes mellitus. Diabetes Research 16:145-148, 1992.
  18. Ziegler AG, Baumgartl HJ, Mühlbauer K, Mehnert S, Standl E. Familienuntersuchung bei Typ-I-Diabetes. Hinweise für eine gemeinsame genetische Komponente von Typ-I- und Typ-II-Diabetes. Diabetes und Stoffwechsel 1:14-17, 1992.
  19. Ziegler AG, Erhard J, Lampeter EF, Nagelkerken LM, Standl E. Involvement of dendritic cells in early insulitis of BB rats. J Autoimmunity 5:571-579, 1992.
  20. Ziegler AG, Mathies R, Ziegelmayer G, Baumgartl HJ, Rodewald A, Chopra V, Standl E. Dermatoglyphics in type 1 diabetes mellitus. Diabetic Medicine 10:720-24, 1993.
  21. Castano L, Ziegler AG, Ziegler R, Shoelson S, Eisenbarth GS. Characterization of insulin autoantibodies in relatives of patients with type 1 diabetes. Diabetes 42:1202-209, 1993.
  22. Ziegler AG, Hillebrand B, Rabl W, Mayrhofer M, Mollenhauer U, Vordemann J, Lenz A, Standl E: On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth. Diabetologia 36:402-408, 1993.
  23. Ziegler AG, Hillebarnd B, Standl E. Inselzellantikörper und Insulin  Autoantikörper bei Schwangeren mit Gestationsdiabetes. Diabetes und Stoffwechsel 2:51-55, 1993.
  24. Roll U, Christie MR, Standl E, Ziegler AG. Association of anti-GAD- antibodies with islet cell antibodies and insulin autoantibodies in first degree relatives of type 1 diabetic patients. Diabetes 43:154-60, 1994.
  25. Baumgartl HJ, Trucco M, Albert E, Mehnert S, Knapp M, Standl E, Ziegler AG. Assoziation von HLA-DQ-Markern und Typ-I-Diabetes in süddeutschen Multiplexfamilien. Diabetes und Stoffwechsel 3:278-282, 1994.
  26. Roll U, Scheeser J, Standl E, Ziegler AG. Alterations of lymphocyte subsets in children of diabetic mothers. Diabetologia 37:1132-1141, 1994.
  27. Durinovic-Bello I, Steinle A, Ziegler AG, Schendel D. HLA-DQ-restricted, islet-specific T cell clones of a type 1 diabetic patient: T cell receptor sequence similarities to insulitis-inducing T cells of nonobese diabetic mice. Diabetes 43:1318-1325, 1994.
  28. Roll U, Nuber A, Schröder A, Gerlach E, Janka HU, Ziegler AG. No association of antibodies to glutamic acid decarboxylase (GAD) and diabetic complications in patients with type 1 (insulin-dependent) diabetes mellitus. Diabetes Care 18:210-215, 1995.
  29. Durinovic-Bello I, Hummel M, Ziegler AG. Cellular immune response to divers islet cell antigens. Diabetes 45:795-801, 1996.
  30. Roll U, Christie MR, Füchtenbusch M, Payton MA, Hawkes CJ, Ziegler AG: Perinatal autoimmunity in offspring of diabetic parents: the German multicenter 'BABY-DIAB' study. Detection of humoral immune responses to islet antigens in early childhood. Diabetes 45:967-973, 1996.
  31. Schnell O, Muhr D, Dresel S, Tatsch K, Ziegler AG, Haslbeck M, Standl E. Autoantibodies against symphathetic ganglia and evidence of cardiac sympathetic dysinnervation in newly diagnosed and long-term IDDM patients. Diabetologia 39:970-975, 1996.
  32. Mayrhofer M, Rabin DU, Messenger L, Standl E, Ziegler AG. Value of ICA512 antibodies for prediction and diagnosis of type 1 diabetes. Exp Clin Endocrinol Diabetes 104:228-234, 1996.
  33. Hummel M, Durinovic-Bello I, Ziegler AG. Relation between cellular and humoral immunity to islet cell antigens in type 1 diabetes. J Autoimmunity  9:427-430, 1996.
  34. Hummel M, Ziegler AG and BABY-DIAB participants: Vaccines and the appearance of islet cell antibodies in offspring of diabetic parents: results from the BABY-DIAB study. Diabetes Care 19:1456-1457, 1996.
  35. Naserke HE, Durinovic-Bello I, Seidel D, Ziegler AG. The T-cell receptor beta chain CDR3-region of BV8S1/BJ1S5-transcripts in type 1 diabetes. Immunogenetics 45:87-96, 1996.
  36. Bingley PJ for the ICARUS group. Interactions of age, islet cell antibodies, insulin autoantibodies, and first phase insulin response in predicting risk of progression to IDDM in ICA+ relatives. Diabetes 45:1720-1728, 1996.
  37. Füchtenbusch M, Karges W, Standl E, Dosch HM, Ziegler AG. Antibodies to bovine serum albumine (BSA) in type 1 diabetes and other autoimmune disorders. Exp Clin Endocrinol Diabetes 105:86-91, 1997.
  38. Weichenhain B, Stemplinger J, Ziegler AG, Rabl W, Standl E, Stiegler H. Alström-Syndrom - eine seltene Erkrankung aus dem diabetischen Formenkreis. Med Klin 92:175-178, 1997.
  39. Endl J, Otto H, Jung G, Meinl E, Hummel M, Ziegler AG, Wank R, Schendel DJ. Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients. J Clin Invest 99:2405-2415, 1997.
  40. Christie MR, Roll U, Payton MA, Hatfield ECI, Ziegler AG. Validity of screening for individuals at risk for type 1 diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care 20:965-970, 1997.
  41. Füchtenbusch M, Ferber K, Standl E, Ziegler AG, and participating centers. Prediction of type 1 diabetes postpartum in patients with gestational diabetes mellitus by combined islet cell autoantibody screening. Diabetes 46:1459-1467, 1997.
  42. Schnell O, Eisfelder B, Standl E, Ziegler AG. High dose intravenous insulin infusion versus intensive insulin treatment in newly diagnosed IDDM. Diabetes 46:1607-1611, 1997.
  43. Muhr D, Mollenhauer U, Ziegler AG, Haslbeck M, Standl E, Schnell O. Autoantibodies to sympathetic ganglia, GAD, or tyrosine phosphatase in long-term IDDM with and without ECG-based cardiac autonomic neuropathy. Diabetes Care 20:1009-1012, 1997.
  44. Dittler J, Seidel D, Schenker M, Ziegler AG. GADIA2-combi determination as first line screening for improved prediction of type 1 diabetes in relatives. Diabetes 47:592-597, 1998.
  45. Füchtenbusch M, Rabl W, Graßl B, Bachmann W, Standl E, Ziegler AG. Delay of type 1 diabetes in high risk first degree relatives by parenteral antigen administration. The Schwabing Insulin Prophylaxis (SIP)-pilot trial. Diabetologia 41:536-541, 1998.
  46. Hummel M, Durinovic-Bello I, Bonifacio E, Lampasona V, Endl J, Fessele S, Trenkwalder C, Standl E, Ziegler AG. Humoral and cellular immune parameters before and during immunsuppressive therapy of a patient with stiff-man syndrome and IDDM. J Neurology, Neurosurgery, Psychiatry 65:204-208, 1998.
  47. Muhr-Becker D, Ziegler AG, Druschky A, Wolfram G, Haslbeck M, Neundörfer B, Standl E, Schnell O. Evidence for specific autoimmunity against sympathetic and parasympathetic nervous tissues in type 1 diabetes mellitus and the relation to cardiac autonomic dysfunction. Diabetic Medicine 15:467-472, 1998.
  48. Naserke H, Dozio N, Ziegler AG, Bonifacio E. Comparison of a novel micro-assay for insulin autoantibodies with the conventional radiobinding assay. Diabetologia 41:681-683, 1998.
  49. Seidel DK, Geiss HC, Donner MG, Ritter MM, Schwandt P, Koll RA, Standl E, Ziegler AG. Course of islet autoantibody tiers during Ig-immunoadsorption in a patient with newly diagnosed type 1 diabetes. J Autoimmunity 11:273-277, 1998.
  50. Hummel M, Banholzer P, Rabl W, Ziegler AG. Organspecific lymph node enlargement in autoimmune polyglandular syndrome. Diabetes Care 21:1573-1574, 1998.
  51. Naserke HE, Ziegler AG, Lampasona V, Bonifacio E. Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes, J Immunology 161:6963-6969, 1998.
  52. Ziegler AG, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for the development of childhood diabetes in offspring of parents with type 1 diabetes: the two year analysis of the BABYDIAB study. Diabetes 48, 460-468,1999.
  53. Schenker M, Hummel M, Ferber K, Walter M, Keller E, Albert ED, Janka HU, Kastendiek C, Sorger M, Louwen F, Ziegler AG. Early expression and high prevalence of islet autoantibodies for DR¾ heterozygous and DR4/4 homozygous offspring of parents with type 1 diabetes: The German BABYDIAB study. Diabetologia 42:671-677, 1999.
  54. Naserke HE, Bonifacio E, Ziegler AG. Immunoglobulin G insulin autoantibodies in BABYDIAB offspring appear postnatally: sensitive early detection using a protein A/G-based radiobinding assay. J Clin Endocrinol Metab 84:1239-1243, 1999.
  55. Bonifacio E, Scirpoli M, Kredel K, Füchtenbusch M, Ziegler AG. Early autoantibody responses in prediabetes are IgG1 dominated and suggest antigen-specific regulation. J Immunology 163:525-532, 1999.
  56. Eaves IA, Bennett ST, Forster P, Ferber KM, Ehrmann D, Wilson AJ, Bhattacharyya, Ziegler AG, Brinkmann B, Todd JA. Transmission ratio distortion at the INS-IGF2 VNTR. Nature Genetics 22:324-325, 1999.
  57. Ferber KM, Keller E, Albert ED, Ziegler AG. Predictive value of HLA class II typing for the development of islet autoantibodies and insulin dependent diabetes postpartum in women with gestational diabetes. J Clin Endocrinol Metab 84 (7):2342-2348, 1999.
  58. Naserke HE, Schenker M, Ziegler AG. Frequency of islet autoantibodies in relatives of patients with type 2 diabetes or gestational diabetes. Diabetologia 42: 1377, 1999 (letter).
  59. Bonifacio E, Bernasconi L, Lampasona V, Ziegler AG. Maturation of the humoral autoimmune response to epitopes of GAD in pre-clinical childhood type 1 diabetes. Diabetes 49:202-208, 2000.
  60. Roll U, Turck CW, Gitelman SE, Rosenthal SM, Nolte MS, Ziegler AG, Baekkeskov S. Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in type 1 diabetic patients. Diabetologia 43:598-608, 2000.
  61. Ziegler AG, Bonifacio E. No inverse relationship between total IgE levels and islet autoimmunity in children of parents with type 1 diabetes. Diabetes Care 23:1205, 2000.
  62. Hummel M, Füchtenbusch M, Schenker M, Ziegler AG. No major association of breast-feeding, vaccinations, and childhood viral diseases with early islet autoimmunity in the German BABYDIAB Study. Diabetes Care 23(7):969-74, 2000.
  63. Kolm-Litty V, Berlo S, Bonifacio E, Bearzatto M, Engel AM, Christie M, Ziegler AG, Wild T, Endl J. Human monoclonal antibodies isolated from type 1 diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen. J Immunology 165: 4676, 2000.
  64. Füchtenbusch M, Kredel K, Bonifacio E, Schnell O, Ziegler AG. Exposure to exogenous insulin promotes IgG1 and the T-helper 2-associated IgG4 responses to insulin but not to other islet autoantigens. Diabetes 49:918, 2000.
  65. Hummel M, Bonifacio E, Stern M, Dittler J, Schimmel A, Ziegler AG. Development of celiac disease-associated antibodies in offspring of parents with type 1 diabetes. Diabetologia 43:1005, 2000.
  66. Hummel M, Heinlein W, Banholzer P, Standl E, Ziegler AG. Erstmanifestation eines Typ 1 Diabetes mit Anämie, Hyperparathyreodismus und abdomineller Lymphadenomatose. Der Internist 42:279-283, 2001.
  67. Schmid S, Schnell O, Bonifacio E, Ziegler AG, Hummel M. Silent celiac disease is not a cause of autonomic neuropathy in patients with type 1 diabetes. Diabetic Medicine 18:683, 2001.
  68. Hummel M, Ziegler AG. Environmental factors and type 1 diabetes - Response to G. Dahlquist. Diabetes Care 24:181-182, 2001.
  69. Hummel M, Schenker M, Ziegler AG. Influence of perinatal factors on the appearance of islet autoantibodies in offspring of parents with type 1 diabetes. Pediatric Diabetes 2:40, 2001.
  70. Hummel M, Ziegler AG, Lewy H, Ashkenazi I, Laron Z. IAA/GAD-positive offspring of diabetic parents have a different seasonality in month of birth than antibody-negative offspring. Diabetes Care 24:2001, 2001.
  71. Hummel M, Williams AJK, Norcross A, Standl E, Bonifacio E, Ziegler AG, Bingley P. Proinsulin-specific autoantibodies are relatively infrequent in young offspring with type 1 diabetes. Diabetes Care 24:1843, 2001.
  72. Bingley PJ, Bonifacio E, Ziegler AG, Schatz DA, Atkinson MA, Eisenbarth GS on behalf of the Immunology of Diabetes Society. Proposed guidelines on screening for risk of type 1 diabetes. Diabetes Care 24:398, 2001.
  73. Naserke H, Bonifacio E, Ziegler AG. Prevalence, characteristics and diabetes risk associated with transient maternally acquired islet antibodies and persistent islet antibodies in offspring of parents with type 1 diabetes (T1D). J Clin Endocrinol Metab 86:4826, 2001.
  74. Füchtenbusch M, Irnstetter A, Jäger G, Ziegler AG. No evidence for an association of Coxsackie virus infection during pregnancy and early childhood with development of islet autoantibodies in offspring of mothers or fathers with type 1 diabetes. J Autoimmunity 17: 333-40, 2001. 
  75. Schnell O, Hammer K, Muhr-Becker D, Ziegler AG, Weiss M, Tatsch K, Standl E. Cardiac sympathetic dysinnervation in Type 2 diabetes mellitus with and without ECG-based cardiac autonomic neuropathy. J Diabetes and Complications 16:220, 2002.
  76. Durinovic-Bello I. Boehm B, Ziegler AG. Predominantly recognized ProInsulin T helper cell epitopes in individuals with and without islet cell autoimmunity. J Autoimmunity, 18: 55-61, 2002.
  77. Bearzatto M, Naserke H, Piquer S, Koczwara K, Lampasona V, Williams A, Christie MR, Bingley P, Ziegler AG, Bonifacio E. Two distinctly HLA associated contiguous linear epitopes uniquely expressed within the IA-2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase like protein autoantigens. J Immunology 168(8):4202-8, 2002.
  78. Schmid S, Molteni A, Füchtenbusch M, Naserke H, Ziegler AG, Bonifacio E. Reduced IL-4 associated immune responses in early pre-diabetes. Diabetologia 45: 677-685, 2002.
  79. Hummel M, Bonifacio E, Naserke HE, Ziegler AG. Elimination of dietary gluten does not reduce titers of type 1 diabetes-associated autoantibodies in high risk subjects. Diabetes Care 25: 1111-1116, 2002.
  80. Walter M, Albert E, Conrad M, Keller E, Hummel M, Ferber K, Barratt B J, Todd A, Ziegler AG, Bonifacio E. IDDM2/insulin VNTR modifies risk conferred by IDDM1/HLA for development of type 1 diabetes and associated autoimmunity. Diabetologia 46: 712-720, 2003.
  81. Koczwara K, Schenker M, Schmid S, Kredel K, Ziegler AG, Bonifacio E. Characterization of antibody responses to endogenous and exogenous antigen in the nonobese diabetic mouse. Clinical Immunology 106: 155-162, 2003.
  82. Herbon N, Werner M, Braig Ch, Gohlke H, Dütsch G, Illig Th, Altmüller J, Hampe J, Lantermann A, Schreiber St, Bonifacio E, Ziegler AG, Schwab S, Wildenauer D, van den Boom D, Braun A, Knapp M, Reitmeir P, Wjst M. High-resolution SNP scan of chromosome 6p21 in pooled samples from patients with complex diseases. Genomics 81: 510-518, 2003.
  83. Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 290:1721-1728, 2003.
  84. Schmid S, Koczwara K, Schwinghammer S, Lampasona V, Ziegler AG, Bonifacio E. Delayed exposure to wheat and barley proteins reduces diabetes incidence in non-obese diabetic mice. Clinical Immunology 111: 108-118, 2004.
  85. Koczwara K, Bonifacio E, Ziegler AG. Transmission of Maternal Islet Antibodies and Risk of Autoimmune Diabetes in Offspring of Mothers With Type 1 Diabetes. Diabetes 53:3017-3020, 2004.
  86. Füchtenbusch M, Bonifacio E, Lampasona V, Knopff A, Ziegler AG. Immune responses to glutamic decarboxylase and insulin in patients with gestational diabetes. Clin Exp Immunol, 135: 318-321, 2004.
  87. Koczwara K, Ziegler AG, Bonifacio E. Maternal immunity to insulin does not affect diabetes risk in progeny of non obese diabetic mice. Clin Exp Immunol, 136: 56-59, 2004.
  88. Achenbach P, Warncke K, Reiter J, Naserke H, Williams AJK, Bingley PJ, Bonifacio E, Ziegler AG. Stratification of Type 1 Diabetes Risk on the Basis of Islet Autoantibody Characteristics. Diabetes 53:384-392, 2004.
  89. Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG. Islet Autoantibody Development and Risk for Childhood Type 1 Diabetes in Offspring of Affected parents. Ann of Internal Med, 140: 882-886, 2004.
  90. Schmid S, Buuck D, Knopff A, Bonifacio E, Ziegler AG: BABYDIET, a feasibility study to prevent the appearance of islet autoantibodies in relatives of patients with Type 1 diabetes by delaying exposure to gluten. Diabetologia 47: 1130-1131, 2004.
  91. Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E: Mature high affinity immune responses to (pro)insulin anticipate the autoimmune cascade leading to type 1 diabetes. J Clin Invest 114: 589-596, 2004.
  92. Bonifacio E, Hummel M, Walter M, Schmid S, Ziegler AG: IDDM1 and multiple family history of type 1 diabetes combine to identify neonates at high risk for childhood diabetes. Diabetes Care 27: 2695-2699, 2004.
  93. Lindsay RS, Ziegler AG, Hamilton BA, Calder AA, Johnstone FD, Walker JD. Scottish Multicentre Study of Diabetes in Pregnancy. Type 1 diabetes-related antibodies in the fetal circulation: prevalence and influence on cord insulin and birth weight in offspring of mothers with type 1 diabetes. J Clin Endocrinol Metab 89, 3436-3439, 2004.
  94. Füchtenbusch M, Ziegler AG, Hummel M. Elimination of dietary gluten and development of type 1 diabetes in high risk subjects. Rev Diab Stud 1, 43-46, 2004.
  95. Hummel M, Ziegler AG, Roth R. Psychological impact of childhood islet autoantibody testing in families participating in the BABYDIAB study. Diabet Med 21, 324-328, 2004.
  96. Viskari H, Ludvigsson J, Uibo R, Salur L, Marciulionyte D, Hermann R, Soltesz G, Fuchtenbusch M, Ziegler AG, Kondrashova A, Romanov A, Knip M, Hyoty H. Relationship between the incidence of type 1 diabetes and enterovirus infections in different European populations: results from the EPIVIR project. J Med Virol 72, 610-617, 2004.
  97. Bonifacio E, Mollenhauer U, Buuck D, Ziegler AG: C-reactive protein concentration is not related to islet autoimmunity status in offspring of parents with type 1 diabetes. Clin Immunol 115: 173-177, 2005.
  98. Viskari H, Ludvigsson J, Uibo R, Salur L, Marciulionyte D, Hermann R, Soltesz G, Füchtenbusch M, Ziegler AG, Kondrashova A, Romanov A, Kaplan B, Laron Z, Koskela P,  Vesikari T, Huhtala H, Knip M, and Hyöty H. Relationship between the incidence of type 1 diabetes and maternal enterovirus antobodies: time trends and geographical variation. Diabetologia 48: 1280-1287, 2005.
  99. Huppmann H, Baumgarten A, Ziegler AG, Bonifacio E. Neonatal Bacille Calmette-Guerin vaccination and type 1 diabetes mellitus. Diabetes Care 28, Number 5: 1204-1206, 2005.
  100. Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, Gorus F, Goldman M, Walter M, Candon S, Schandene L, Crenier L, De Block C, Seigneurin JM, De Pauw P, Pierard D, Weets I, Rebello P, Bird P, Berrie E, Frewin M, Waldmann H, Bach JF, Pipeleers D, Chatenoud L. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 25, 2642-2644, 2005.
  101. Schlosser M, Koczwara K, Kenk H, Strebelow M, Rjasanowski I, Wassmuth R, Achenbach P, Zieger AG, Bonifacio E. In insulin-autoantibody-positive children from the general population, antibody affinity identifies those at high and low risk. Diabetologia 48: 1830-1832, 2005.
  102. Löbner K, Knopff A, Baumgarten A, Mollenhauer U, Marienfeld S, Garrido-Franco M, Bonifacio E, Ziegler AG. Predictors of postpartum diabetes in women with gestational diabetes mellitus. Diabetes 55: 792-797, 2006.
  103. Hummel M, Schaaf L, Füchtenbusch M, Standl E, Ziegler AG. Hypertonie, Hypokaliämie und rasch progrediente Ödeme bei einem 62-jährigen Diabetiker. Der Internist 4: 427-433, 2006.
  104. TEDDY Investigators. TEDDY The Environmental Determinants of Diabetes in the Young. An observational clinical trial. Annals of New York Academy of Sciences, Volume: Immunology of Diabetes IV: progression in understanding, 1079:320-326, 2006. 
  105. Achenbach P, Warncke K, Reiter J, Williams AJK, Ziegler AG, Bingley PJ, Bonifacio E. Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives. Diabetologia 49:2969-2976, 2006.
  106. Hummel S, Hummel M, Banholzer J, Hanak D, Mollenhauer U, Bonifacio E, Ziegler AG. Development of autoimmunity to transglutaminase C in children of patients with type 1 diabetes: relationship to islet autoantibodies and infant feeding. Diabetologia 50: 390-394, 2007.
  107. Hummel S, Winkler C, Schoen S, Knopff A, Marienfeld S, Bonifacio E, Ziegler AG: Breast feeding habits in families with type 1 diabetes. Diabet Med 24:671-676, 2007.
  108. Hummel M, Baumgarten A, Hummel S, König S, Ziegler AG: Smoking behavior during pregnancy of women with type 1 or gestational diabetes. Dtsch Med Wochenschr. 2132(21):1153-1158, 2007.
  109. Hummel M, Marienfeld S, Huppmann M, Knopff A, Voigt M, Bonifacio E, Ziegler AG. Interaction between maternal type 1 diabetes and HLA DR4 increases fetal growth. Diabetologia 50:850-8, 2007.
  110. Mayr A, Schlosser M, Grober N, Kenk H., Ziegler AG, Bonifacio E, Achenbach P: GAD Autoantibody Affinity and Epitope Specificity Identify Distinct Immunization Profiles in Children at Risk for Type 1 Diabetes. Diabetes 56: 1527-1533, 2007.
  111. Koczwara K, Müller D, Achenbach P, Ziegler AG, Bonifacio E. Insulin autoantibodies of IgA isotype that preferentially target non-human insulin. Clin Immunol 124 (1): 77-82, 2007.
  112. Monti P, Scirpoli M, Rigamonti A, Mayr A, Jaeger A, Bonfanti R, Chiumello G, Ziegler AG, Bonifacio E : Evidence for in vivo primed and expanded autoreactive T Cells as a specific feature of patients with type 1 diabetes. The Journal of Immunology, 179: 5785-5792, 2007.
  113. Kiviniemi M, Hermann R, Nurmi J, Ziegler AG, Knip M, Simell O, Veijola R, Lövgren T, Ilonen J; TEDDY Study Group. A high-throughput population screening system for the estimation of genetic risk for type 1 diabetes: an application for the TEDDY (the Environmental Determinants of Diabetes in the Young) study. Diabetes Technol Ther.;9(5):460-72, 2007.
  114. Bonifacio E, Mayr A, Knopff A, Ziegler AG. Thyroid autoimmunity frequently appears during late childhood or adolescence in families susceptible for autoimmune diabetes. Diabetologia 2008.
  115. Achenbach P, Bonifacio E, Williams AJK, Ziegler AG, Gale EAM, Bingley PJ, and the ENDIT Group. 2008 Autoantibodies to IA-2β improve diabetes risk assessment in high risk relatives. Diabetologia 51(3):488-92, 2008.
  116. Bonifacio E, Mayr A, Knopff A, Ziegler AG. Endocrine autoimmunity in families with type 1 diabetes: frequent appearance of thyroid autoimmunity during late childhood and adolescence. Diabetologia, 2008.
  117. Bonifacio E, Pflüger M, Marienfeld S, Winkler C, Hummel M, Ziegler AG. Maternal type 1 diabetes reduces the risk of islet autoantibodies: relationship with birtweight and maternal HbA1c. Diabetologia 51(7):1245-52, 2008.
  118. Füchtenbusch M, Hummel M.: Intensive blood sugar treatment in type 2 diabetics: no evidence for increased mortality in the ADVANCE study compared with ACCORD study,MMW Fortschr Med.;150(17):42-4, 2008.
  119. Görlitz N, Keller M, Ziegler AG. Prävalenzen von Folge- und Begleiterkrankungen des Typ 2 Diabetes. Querschnittuntersuchungen an DMP-Teilnehmern in Bayern. DMW 133:1667-1672, 2008.
  120. Gohlke H, Ferrari U, Koczwara K, Bonifacio E, Illig T, Ziegler AG. SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes onset. Rev Diabet Stud 5(1):25-27, 2008.
  121. Hummel M, Geigenberger G, Brand J, Ziegler AG, Füchtenbusch M.:New therapeutic approaches to diabetic gastroparesis, Med Klin (Munich);103(7):514-8. 2008.
  122. Hummel S, Hummel M, Knopff A, Bonifacio E, Ziegler AG: Stillverhalten bei Frauen mit Gestationsdiabetes. DMW 133(5):180-184, 2008.
  123. Kreichauf S, Pflüger M, Hummel S, Ziegler AG: Einfluss des Stillens auf das Risiko für Übergewicht bei Kindern von Müttern mit Typ 1 Diabetes. DMW 133:1173-1177, 2008.
  124. Schoen S, Sichert-Hellert W, Hummel S, Ziegler AG, Kersting M. Breastfeeding duration in families with type 1 diabetes compared to non-affected families: results from BABYDIAB and DONALD studies in Germany. Breastfeed Med 3(3):171-175, 2008.
  125. Winkler C, Hummel S, Pflüger M, Ziegler AG, Geppert J, Demmelmair H, Koletzko B. The effect of maternal T1DM on the fatty acid composition of erythrocyte phosphatidylcholine and phosphatidyethanolamine in infants during early life. Eur J Nutr. 47(3):145-52, 2008.
  126. Winkler C, Mollenhauer U, Hummel S, Bonifacio E, Ziegler AG. Exposure to Environmental Factors in Drinking Water: Risk of Islet Autoimmunity and Type 1 Diabetes – The BABYDIAB Study. Horm Metab Res 40:566-571, 2008.
  127. Achenbach P, Lampasona V, Landherr U, Koczwara K, Krause S, Grallert H, Winkler C, Pflüger M, Illig T, Bonifacio E, Ziegler AG. Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia 52 (9):1881-88, 2009.
  128. Bonifacio E, Mayr A, Knopff A, Ziegler AG. Endocrine autoimmunity in families with type 1 diabetes: frequent appearance of thyroid autoimmunity during late childhood and adolescence. Diabetologia 52(2):185-92, 2009.
  129. Badenhoop K, Kahles H, Seidl C, Kordonouri O, Lopez ER, Walter M, Rosinger S, Ziegler A, Böhm BO and the Type 1 Diabetes Genetics Consortium. MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth. Diabetes, Obesity and Metabolism 11 (Suppl.1):88-91, 2009.
  130. Hummel M, Füchtenbusch M. Case Report: A new  combination therapy of diabetic gstroparesis. Zeitschrift für Gastroenterologie 47:1216-20 , 2009.
  131. Hummel S, Pflüger M, Kreichauf S, Hummel M, Ziegler AG. Predictors of Overweight during Childhood in Offspring of Parents with Type 1 Diabetes. Diabetes Care 32 (5):921-25, 2009.
  132. Hummel S, Pflüger M, Kreichauf S, Hummel M, Ziegler AG. Predictors of Overweight during Childhood in Offspring of Parents with Type 1 Diabetes: Response to Rodekamp et al.. Diabetes Care 32 (11):e139, 2009.
  133. Keymeulen B, Walter M, Mathieu C, Kaufman L, Gorus F, Hilbrands R, Vandemeulebroucke E, Van de Velde U, Crenier L, De Block C, Candon S, Waldmann H, Ziegler AG, Chatenoud L, Pipeleers D. Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass. Diabetologia 2010 April; 53(4): 614-23.
  134. Mueller DB, Koczwara K, Mueller AS, Pallauf J, Ziegler AG, Bonifacio E. Influence of early nutritional components on the development of murine autoimmune diabetes. Ann Nutr Metab 54:208-17, 2009.
  135. Pechhold K, Koczwara K, Zhu X, Harrison VS, Walker G, Lee J, Harlan DM. Blood glucose levels regulate pancreatic beta-cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice. PloS ONE 4(3):e4827, 2009.
  136. Pechhold K, Zhu X, Harrison VS, Lee J, Chakrabarty S, Koczwara K, Gavrilova O, Harlan DM. Dynamic changes in pancreatic endocrine cell abundance, distribution, and function in antigen-induced and spontaneous autoimmune diabetes. Diabetes 58(5):1175-84, 2009.
  137. Walter M, Philotheou A, Bonnici F, Ziegler AG, Jimenez R. No effect of the altered peptide ligand NBI-6024 on ß-cell residual function and insulin needs in new-onset type 1 diabetes. Diabetes Care 32 (11):2036-40, 2009.
  138. Winkler C, Illig T, Koczwara K, Bonifacio E, Ziegler AG. HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes. J Clin Endocrinol Metab.94 (10):4113-5, 2009.
  139. Winkler C, Marienfeld S, Zwilling M, Bonifacio E, Ziegler AG. Is islet autoimmunity related to insulin sensitivity or body weight in children of parents with type 1 diabetes? Diabetologia 52(10):2072-8, 2009.
  140. Pflüger M, Winkler C, Hummel S, Ziegler AG. Early infant diet in children at high risk for typ 1 diabetes. Horm Metab Res 42:143-8, 2010.
  141. Keymeulen B, Candon S, Fafi-Kremer S, Ziegler A, Leruez-Ville M, Mathieu C, Vandemeulebroucke E, Walter M, Crenier L, Thervet E, Legendre C, Pierard D, Hale G, Waldmann H, Bach JF, Seigneurin JM, Pipeleers D, Chatenoud L.Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients. Blood 115(6)1145-55, 2010.
  142. Hale G, Rebello P, Al Bakir I, Bolam E, Wiczling P, Jusko WJ,  Vandemeulebroucke E, Keymeulen B, Mathieu C, Ziegler AG, Chatenoud L, Pipeleers D, Waldmann H. Pharmacokinetics and antibody responses to the CD3 antibody otelixizumab used in the treatment of Type I diabetes. Journal of Clinical Pharmacology 2010 Febr. Epub ahead of print. PMID: 20147616.
  143. Walter M, Kaupper T, Adler K, Foersch J, Bonifacio E, Ziegler AG. No Effect of the 1α,25-dihydroxyvitamin D3 on Beta Cell Residual Function and Insulin Requirement in New-Onset Type 1 Diabetes. Diabetes Care 2010 Mar 31. Epub ahead of print. PMID: 20357369.
  144. Bonifacio E, Yu l, Williams A, Eisenbarth G, Bingley P, Marcovina S, Koczwara K, Ziegler A, Mueller P, Schatz D, Krischer J, Steffes M, Akolkar B. Harmonization of GAD – and IA-2 autoantibody assays for NIDDK consortia. J Clin Endocrinol Metab. 2010 May 5. Epub ahead of print. PMID: 20444913.
  145. Wenzlau JM, Walter M, Gardner TM, Frisch LM, Yu Liping, Eisenbarth GS, Ziegler AG, Davidson HC, Hutton JC. Kinetics of the post onset decline in Zink Transporter 8 autoantibodies in type 1 diabetic human subjects. Journal of Autoimmunity accepted 2010.
  146. Winkler C, Bonifacio E, Grallert H, Henneberger L, Illig T, Ziegler AG. BMI at age of 8 years is influenced by the type 2 diabetes susceptibility genes HHEX-IDE and CDKAL1. Diabetes. 2010 May 11. Epub ahead of print. PMID: 20460429.